反复呼吸道感染儿童血清12种微量元素、T细胞亚群检测及其相关性探讨

RELATIONSHIP BETWEEN 12 KINDS OF TRACE ELEMENTS IN SERUM AND T LYMPHOCYTE SUBSETS IN CHILDREN

检测９２例反复呼吸道感染（ＲＲＴＩ）患儿血清Ｚｎ、Ｍｎ、Ａｌ、Ｃｄ、Ｆｅ、Ｃｕ、Ｐｂ、Ｎｉ、Ｔｉ、Ｃｏ、Ｌｉ、Ｃｒ含量，以及外周血Ｔ细胞亚群、Ｔ细胞增殖功能、血清免疫球蛋白等指标，结果表明ＲＲＴＩ患儿血清Ｚｎ、Ｆｅ、Ｐｂ、Ｎｉ、Ｔｉ、Ｃｏ、Ｌｉ均值明显低于正常对照组，各年龄中亦以Ｚｎ、Ｆｅ、Ｃｏ、Ｌｉ降低多见；外周血Ｔ细胞增殖功能、ＣＤ３＋细胞百分率、ＣＤ４＋细胞百分率以及ＣＤ４＋／ＣＤ８＋细胞比值均显著下降，ＣＤ８＋细胞百分率明显高于正常儿童。上述免疫功能指标与血清Ｆｅ、Ｚｎ、Ｃｒ、Ｎｉ等存在显著性相关关系。提示ＲＲＴＩ时不仅免疫功能广泛受损，而且伴有多种微量元素缺乏或失衡；血清微量元素缺乏、免疫功能低下与ＲＲＴＩ三者间可能互为因果，临床上及时补充铁、锌等微量元素对防治ＲＲＴＩ的发生发展是十分必要的。

The concentrations of Zn, Mn, Al, Cd, Fe, Cu, Pb, Ni, Ti, Co, Li, Cr in serum and change of T lymphocyte subsets and its proliferative response in peripheral blood,and the level of immunoglobulin(Ig) were measured in 92 children with recurrent respiratory tract infections(RRTI). The mean of serum Zn, Fe, Pb, Ni, Ti, Co, Li was decreased and deficiency of Zn, Fe,Li,Co was common in every ages group. There were obvious decrease in T lymphocyte proliferation response, percentage of CD3+ and CD4+ cell, ratio of CD4+/CD8+ and increase in percentage of CD8+ cell in children with RRTI. There was a significant correlation between indicatrixes of immunofunctions and serum Fe, Zn, Cr, Ni. The result suggests that RRTI not only injures the function of immunity, but also has many kinds of trace elements deficiency or imbalance in children. There may be a causal relation amang serum trace elements deficiency ,immunodeficiency and RRTI. Replenishing trace elements(Fe, Zn, etc.) is important in preventing children from the attack of RRTI.