男性青少年肥胖患者血清瘦素与睾酮、雌二醇联合检测的临床价值研究

Clinical Value of Combined Determining Leptin,T and E_2 in Male Teenager Obesity Patients

为探讨男性青少年肥胖患者血清瘦素、T、E2联合检测的临床价值,用RIA对男性青少年肥胖患者和成年男性肥胖患者进行血清瘦素、T、E2的联合检测,并对两组患者进行了治疗前和治疗后的比较。结果表明:肥胖组与对照组比较,瘦素、E2明显增高,T明显降低。青少年肥胖患者治疗后与治疗前相比较瘦素、E2明显降低,T明显增高;成年肥胖组治疗前、后瘦素明显降低,E2、T无明显变化。瘦素、E2、T同时检测可以及早发现肥胖青少年的内分泌代谢紊乱及青春期发育障碍。

To study clinical significance of combined detection of leptin, T and E2 for teenager obesity patients, levels of leptin, T and E2 in male teenagers obesity patients and male adult obesity patients were determined by RIA. The result showed that in all obesity patients, the levels of leptin and E2 were much higher than those in normal controls and T was lower than that in normal controls. After treatment, leptin and E2 were decreased and T was increased significantly in teenager obesity patients, but only leptin was decreased in adult obesity patients. All resuits indicate that combined detection of leptin, T and E2 could find endocrine and metabolism disorder of obese teenagers at early stage, instituting prevention and treatment without delay.