摘要
2-溴-4-氟苯甲酰肼(1)与芳香醛缩合得到酰腙(2a^2i),再与丙酸酐环反应合成了9种新型的2-芳基-3-N-丙酰基-5-(2-溴-4-氟苯基)-1,3,4-二唑啉类衍生物(3a^3i),收率79%~84%。化合物的结构经元素分析、IR、1HNMR和MS确证。初步的抗菌试验表明,部分目标化合物表现出较好的抑菌活性。
Condensation of 2-bromo-4-fluorobenzoyl hydrazine (1) with aromatic aldehydes produced corresponding hydrazones(2a-2i). Cyclization of 2a-2i with propanoic anhydide gave the title compounds 3a- 3i in good yields of 79.3% -85.5 %. Their structures were characterized by means of elemental analysis, IR, 1^H NMR and MS spectra. The preliminary antibacterial tests showed that most of them had good antibacterial activities.
出处
《应用化学》
CAS
CSCD
北大核心
2006年第8期936-938,共3页
Chinese Journal of Applied Chemistry
基金
湖北省教育厅2004年科学技术研究项目(2004D001)
关键词
噁二唑啉衍生物
合成
结构表征
抑菌活性
oxadiazoline derivative, synthesis,structural characterization,antibacterial activity