宫颈粘液抗精子抗体与不明原因不孕

ANTISPERM-ANTIBODIES IN CERVICAL MUCUS WITH UNEXPLAINED INFERTILITY

本文对２６例不明原因不孕和１７例已育健康妇女，采用混合抗人球蛋白试验测定排卵日宫颈粘液及血清中抗精子抗体（ＡｓＡｂ）．同时用Ｂ超、尿ＬＨ酶标单克隆抗体免疫测定、宫颈粘液改良Ｉｎｓｌｅｒ评分等联合监测预测排卵和确定排卵日。结果表明：不孕组宫颈粘液ＡｓＡｂ阳性率２３．０８％，明显高于生育组５．８８％（Ｐ＜０．０５）；性交后试验（ＰＣＴ）异常组宫颈粘液ＡｓＡｂ阳性率显著高于生育组（Ｐ＜０．０５），而ＰＣＴ正常组则与生育组无统计学差异（Ｐ＞０．０５）。研究提示：宫颈粘液中抗精子抗体结合ＰＣＴ可正确地评价宫颈因素的不孕。

ntisperm-antibodies[AsAb] in cervical mucus and serum of 26 unexplained infertilewomen and 17 matched controls in the ovulating day were measured by mixed agglutination reac-tion。 To predict the ovulating day, B mode ultrasonography,urine LH measured by enzyme-labeledmonoclonal antioody immunoassay, modified insler score of the cervical mucus and basic bodytemperature were simultaneously performed during menstrual cycles. The results showed that cer-vical mucus AsAb in infertile women were significantly higher than that in fertile women(P<0.05),were also higher in Postcoital test(PCT)abnormal group compared with fertile women(P>0.05),however,there were no statistical difference between PCT normal group and fertilewomen( P >0.05).The study indicates that AsAb in cervical mucus combined with PCT may es-timate the cervical infertility more correctly。