下咽癌78例术后放疗临床疗效及预后分析

Clinical study on postoperative radiotherapy of 78 cases with hypopharyngeal carcinoma

目的探讨下咽癌手术+术后放疗的临床疗效及影响下咽癌生存率和局控率的因素。方法回顾性分析1979年2月￣2001年4月收治的手术+术后放疗下咽癌78例,Kaplan-Meier法分析3、5年生存率和局控率,Logrank进行单因素分析,Cox模型进行多因素分析。结果60例手术+术后下咽癌放疗下咽癌病人3、5年生存率分别为58.1%和41.9%,3、5年局控率分别为82.3%和75.6%。多因素分析显示T分期,N分期以及临床分期是影响下咽癌生存率的独立预后因素;T分期和临床分期是影响下咽癌局控率的独立预后因素。结论T分期,N分期和临床分期是影响下咽癌长期生存的独立预后因子,T分期和临床分期是影响下咽癌局控率的独立预后因子。

[Objective] To evaluate postoperative radiotherapy clinical effect of hypopharyngeal carcinoma and identify the prognostic variable related to hypopharyngeal carcinoma. [Methods] A statistic analysis of the clinical results and prognostic factors were performed on the 78 patients with hypopharyngeal carcinoma treated by postoperative radiotherapy. Kaplan-Meier method was used for the survival rate and local control rate, Cox proportional hazard model in multivariate analysis. [Results] The 3, 5year survival rate were 58.1%, 41.9%; the 3, 5 year local control rate were 82.3%, 75.6%. By multivariate analysis, T stang ,N stage and clinical stage were three independent prognostic factors in survival rate; T stage, clinical stage were two independent factors in local control rate. [ Conelusions] T stage, N stage and chnical stage were independent prognostic factors in- fluencing remote survival by Cox regression model. And T stage, chnical stage possess independent prognostic value on the local control rate.