卡铂、5－Fu序贯腔内用药治疗癌性腹水

Intraperitoneal Carboplatin and 5-Fu in Sequence in the Treatment of Malignant Ascites

作者对５０例癌性腹水病人应用卡铂．５－Ｆｕ序贯腔内给药治疗，其中完全缓解（ＣＲ）２２例，占４４％，部分缓解（ＰＲ）２４例，占４８％，总有效率（ＣＲ＋ＰＲ）为９２％，毒副作用主要表现为恶心、厌食，偶见低热、腹痛和一过性白细胞下降，表明本疗法对癌性腹水近期疗效高，毒性低、缓解期长，值得在基层医院推广。

Fifty cases of malignant ascites were treated with Carboplatin and 5 -Fluorourail intraperitoneal administration in sequence.Of the 50 patients,22 patients(44%) achieved CR,24(48%)PR and 4(8%) NC.The total response rate was 92%(22+24/50).The main clinical side- effects were nausea,anorexia,occasional slight fever,abdominal pain and temporary leukopenia.In conclusion,the curative effect of this therapy was better and the toxicity was mild,and therefore it was worth spreading in basic local clinical units.