金葵胃药对实验性胃黏膜损伤的保护作用及其机制

Protective effect of Jinkui Gastric Drug on experimental gastric mucosal lesion and its mechanism

目的:观察金葵胃药(JK)对胃粘膜损伤的保护作用,并探讨其机制。方法:采用阿司匹林灌胃致大鼠胃黏膜损伤模型,观察JK用药组和对照组胃黏膜损伤指数,并测定血清和胃组织中一氧化氮(NO)含量和一氧化氮合酶(NOS)活性,测定血浆中6-酮-前列腺素F1α(6-keto-PGF1α)、血栓素B2(TXB2)和血清中表皮生长因子(EGF)含量。结果:JK用药组的胃黏膜损伤指数较模型对照组显著下降,血清和胃组织中NO含量和NOS活性显著升高,血浆6-keto-PGF1α、TXB2含量和血清EGF含量明显升高。结论:JK对实验性胃黏膜损伤具有保护作用,其机制可能与增高胃黏膜保护因子有关。

AIM： To investigate the protective effects and its mechanism of Jinkui Gastric Drug（JK）. METHODS： The model of gastric mucosal lesion in rats induced by hydrochloride acid-aspirin was used. The indexes of gastric mucosal lesion in JK and control groups were observed. The contents of nitric oxide （NO） and the activity of nitric oxide synthase （NOS） in blood serum and gastric tissue in rats, the levels of 6-keto-PGF1α, thromboxane B2 （TXB2 ） in blood plasma and epidermal growth factor （EGF） in blood serum were examined. RESULTS： The index of gastric mucosal lesion after administration of JK reduced obviously. The contents of NO and the activity of NOS in serum and gastric tissue increased markedly. The levels of 6-keto-PGF1α, TXB2 and EGF increased significantly. CONCLUSION： JK can protect experimental gastric mucosal lesion and its mechanism may be related to increasing the protective factors.