期刊文献+

系统生物学——药物研发的新动力 被引量:2

Systems biology:a new drive for drug research and development
下载PDF
导出
摘要 系统生物学是研究生物系统中所有组成成分以及特定条件下这些组分间相互关系的学科。它以干涉生物活动过程及人工模拟为主要手段,以生物信息为基础,是近年提出的新研究领域,其主要特点是对已有生命科学认识的系统整合。系统生物学的理论与方法以及相关的研究结果将为新药研发以及中医药研究提供新的视角与手段,成为药物研究的新动力。 Systems biology is the analysis of the elements and their relationships in a system in response to genetics or environmental perturbations. Systems biology, based on bio-information and resorted to perturbation and simulation, is a new field and branch of biology, which integrates all aspects of life sciences as a whole. The theory, methods and related research outcomes of systems biology will provide new perspectives and means for discovery, research and development for both western medicine and Traditional Chinese Medicine. Systems biology will become a new drive of drug research and development.
出处 《中国新药杂志》 CAS CSCD 北大核心 2006年第19期1626-1630,共5页 Chinese Journal of New Drugs
关键词 系统生物学 新药发现 新药研发 中医药 systems biology drug discovery drug research and development Traditional Chinese Medicine
  • 相关文献

参考文献26

  • 1THE NEWS STAFF. Breakthrough of the year: the runners-up[J]. Science,2005, 310 (5756) :1880 - 1885.
  • 2KITANO H. Systems biology : a brief overview [ J ]. Science,2002, 295 (5560) : 1662 - 1664.
  • 3WESTON AD,HOOD L. Systems biology, proteomics,and the future of health care : toward predictive, preventative, and personalized medicine [ J ]. J Proteome Res, 2004,3 ( 2 ) : 179 - 196.
  • 4IDEKER T, GALITSKI T,HOOD L. A new approach to decoding life : Systems Biology [ J ]. Annu Rev Genomics Hum Genet, 2001,2:343 - 372.
  • 5HOOD L, PERLMUTTER RM. The impact of systems approaches on biological problems in drug discovery[ J]. Nat Biotechnol, 2004, 22(10) :1215 - 1217.
  • 6蒋太交,薛艳红,徐涛.系统生物学——生命科学的新领域[J].生物化学与生物物理进展,2004,31(11):957-964. 被引量:23
  • 7BUTCHER EC. Can cell systems biology rescue drug discovery[J]. Nat Rev Drug Discov, 2005, 4(6) :461 -467.
  • 8BUTCHER EC, BERG EL, KUNKEL EJ. Systems biology in drugdiscovery[ J]. Nat Biotechnol, 2004, 22(10) :1253 - 1259.
  • 9DAVIDOV EJ, HOLLAND JM, MARPLE EW,et al. Advancing drug discovery through systems biology[ J]. DDT, 2003, 8 (4) :175 - 183.
  • 10LEE DY, ZIMMER R, LEE SY. Knowledge representation model for systems-level analysis of signal transduction networks[J].Genome Inform, 2004, 15(2) :234 -243.

二级参考文献37

  • 1Mangan S, Alon U. Structure and function of the feed-forward loop network motif. Proc Natl Acad Sci USA, 2003, 100 (21): 11980- 11985
  • 2Yeger-Lotem E, Sattath S, Kashtan N, et al. Network motifs in integrated cellular networks of transcription-regulation and proteinprotein interaction. Proc Natl Acad Sci USA, 2004, 101 (16):5934 - 5939
  • 3Maslov S, Sneppen K. Specificity and stability in topology of protein networks. Science, 2002, 296 (5569): 910 -913
  • 4Han J D, Bertin N, Hao T, et al. Evidence for dynamically organized modularity in the yeast protein-protein interaction network.Nature, 2004, 430 (6995): 88 -93
  • 5Luscombe N M, Madan Babu M, Yu H, et al. Genomic analysis of regulatory network dynamics reveals large topological changes.Nature, 2004, 431 (7006): 308 -312
  • 6Wuchty S, Oltvai Z N, Barabasi A L. Evolutionary conservation of motif constituents in the yeast protein interaction network. Nat Genet, 2003, 35 (2): 176-179
  • 7Wolf D M, Arkin A P. Motifs, modules and games in bacteria. Curr Opin Microbiol, 2003, 6 (2): 125 - 134
  • 8Goldbeter A. Computational approaches to cellular rhythms. Nature,2002, 420 (6912): 238-245
  • 9Holtzendorff J, Hung D, Brende P, et al. Oscillating global regulators control the genetic circuit driving a bacterial cell cycle.Science, 2004, 304 (5673): 983-987
  • 10Stelling J, Sauer U, Szallasi Z, et al. Robustness of cellular functions. Cell, 2004, 118 (6): 675 -685

共引文献22

同被引文献28

  • 1陈凯先.21世纪中医药发展的战略思考[J].世界科学技术-中医药现代化,2007,9(1):6-9. 被引量:16
  • 2US Food and Drug Administration. Challenge and opportunity on the critical path to new medical products[ EB/OL]. [2004 -03 - 16]. http://www, fda. gov/oc/initiatives/critiealpath/whitepaper. html.
  • 3LI WAN PO A. Drug evaluation,drug development and pharmacogenetics:celebrating 30 years of progress [J]. J Clin Pharm Ther, 2005,30(1 ) :1 -4.
  • 4KUMAR N, HENDRIKS BS,JANES KA, et al. Applying computational modeling to drug discovery and development [ J ]. Drug Discov Today,2006,11( 17-18 ) :806 - 811.
  • 5HOOD L. Systems biology:integrating technology, biology and computation [ J ]. Mech Ageing Dev,2003,124 ( 1 ) :9 - 16.
  • 6MICHELSON S. The impact of systems biology and biosimulation on drug discovery and development [ J ]. Mol Biosyst, 2006,2 (6-7) :288 -291.
  • 7HOOD L, HEATH JR, PHELPS ME, et al. Systems biology and new technologies enable predictive and preventative medicine[J]. Science,2004,306 ( 22 ) : 640 - 643.
  • 8KUNKEL EJ,DEA M,EBENS A,et al. An integrative biology approach for analysis of drug action in models of human vascular inflammation[ J]. FASEB J,2004,18( 11 ) :1279 - 1281.
  • 9KUNKEL EJ,PLAVEC I, NGUYEN D,et al. Rapid structure-activity and selectivity analysis of kinase inhibitors by BioMAP analysis in complex human primary cell-based model[J]. Assay Drug Dev Technol,2004,2 ( 4 ) :431 - 441.
  • 10BERG EL, KUNKEL E J, EVANGELOS H, et al. Characterization of compound mechanisms and secondary activities by BioMAP analysls[ J]. J Phamacol Toxicol Methods ,2006,53 ( 1 ) :67 - 74.

引证文献2

二级引证文献3

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部