山羊心肌可透析提取物对小鼠脾淋巴细胞RNA合成的影响

The Effect of Dialysable Extracts from Cardiac Muscle of Goat on the RNA Synthesis of Murine Splenic Lymphocytes

山羊心肌可透析提取物能增强conA刺激的小鼠脾淋巴细胞体外RNA合成。在最适浓度下,这种作用较由同一山羊淋巴组织制备的转移因子(TF)为强(P<0.05),而与免疫所用抗原无关。由免疫与非免疫山羊心肌制备的可透析提取物的增强作用无差异。TF与山羊心肌可透析提取物混合使用呈现无关作用。作者认为心肌可能成为制备TF类似物新的原料来源。该提取物对特异性免疫反应的影响有待进一步研究。

This paper describes that dialysable extracts from cardiac muscle of the goat could augment the RNA synthesis in vitro in murine splenic lymphocytes stimulated by con A at the optimum concentration. The activity is higher than that of the transfer factor prepared from the lymphoid tissue of the same goats (P<0.05), which is independent of the antigens used in immunized goats. There is no difference between the augment activities of myocardial dialysable extracts from cardiac muscle of immunized goat or non-immunized goat. Indifference is shown in simultaneous addition cf transfer factor and the dialysable extracts from cardiac muscle of goats. It is considered that the cardiac muscle of goat may serve as a new resource of raw materials in preparing transfer factor-like substance. The effects of the dialysable extracts on special immune response remain an area for study.