不同剂量γ-干扰素对胃结肠癌病人术后免疫功能的影响

Influence of different dose γ-IFN on the immune function of stomach and colon cancer

目的 探讨小剂量γ-干扰素（γ-IFN）对胃结肠癌病人术后免疫功能的影响。方法选择55例胃结肠癌术后病例随机分为3组，A、B为不同剂量治疗组，C为对照组。检测各组免疫学指标，观察比较CD3^＋、CD4^＋、CD8^＋、NK、ILγ-变化以及毒副作用发生情况。结果治疗组A、B组自身比较，在应用γ-IFN前后CD4^＋、NK、IL-2均有明显升高（P〈0．05）；治疗组A、B间组间比较各项指标虽有差异，但无统计学意义；治疗组A、B组与对照组C组间比较应用γ-IFN后CD4^＋、NK、IL-2明显增高；对照组C在同期其各项指标都显示降低趋势。治疗B组毒副作用发生较A组明显增高。结论 小剂量持续应用γ-IFN能有效提高胃结肠癌术后病人的机体抗肿瘤的能力。

AIM To investigate the influence of different dose γ-IFN on the immune function of stomach and colon cancer. METHODS 55 patients were randomly divided into 3 groups. A and B is different doses group respectively, C is a control group. Compared with the changes on cellulla immunity function between 3 groups. RESULTS CD4, NK, IL- 2 were significantly higher in group A and B after using γ-IFN （ P 〈0.05）. The minimum dose was associated with fewer toxic side effects. CONCLUSION γ-IFN given with lower dose is helpful to improve the immune function and antitumor effects of stomach and colon cancer.