既往有偿献血人员HIV感染者自然史分析

The natural history of HIV infection among paid blood donors in Henan province

目的了解既往有偿献血人员HIV感染自然史。方法采用回顾性分析,结合横断面研究,对来自河南省12个村庄的2 364例经有偿献血感染HIV的患者进行观察。结果截止2004年底,2 364例HIV/AIDS患者中共死亡709例,HIV感染者总病死率为30.1%。在死亡原因中,严重的肺部感染占32.8%,严重腹泻占18.1%,中枢神经系统占8.2%,肝硬化占8.2%,各种肿瘤占6.6%,自杀占3%,死于AIDS晚期或不明原因死亡占23%。其中,在未进行艾滋病抗病毒治疗的2002年底之前,共死亡544例,死亡率为23.0%。推算中位生存期为9.5年,中位潜伏期约为8.5年。结论农村地区经有偿献血感染HIV者的中位生存期约为9.5年,中位潜伏期约为8.5年。

Objective To study the natural history of HIV infection among paid blood donors（PBD）.Methods Two thousand three hundred and sixty four individuals infected with HIV/AIDS via blood donation in twelve villages of Henan province were included in this study, Retrospective data were analyzed in combination with a cross-sectional survey. Results The number of deaths were 709 among these 2 364 subjects under study by the end of 2004, with a mortality rate of 30.1% .Among 712 deaths, 32.8 % were companied with serious lung infections, 18.1% were complicated with serious diarrhea, 8.2 % -with central nervous infections, 8.2 % -with cirrhosis, 6.6 % -with various types of cancers, 3 % died of suicide and 23 % died with unclear cause. Of them 544 AIDS patients died before the ARV treatment was available in rural areas of Henan at the end of 2002, with a mortality rate of 23.0 %. The median survival period for individuals with HIV infection was 9.5 years, and the median incubation period was about 8.5 years.Conclusion The median aurvival period for individuals with HIV infection via blood donation in rural areas of Henan was 9.5 years and the median incubation period was about 8.5 years among them.