摘要
目的研究针刺对多发梗塞性痴呆大鼠(MID)空间学习记忆的改善作用。方法颈外动脉逆行插管注入血栓建立MID模型,并进行针刺治疗,应用Morris水迷宫检测MID大鼠的空间学习记忆的变化,HE染色观察皮层及海马的形态变化。结果MID大鼠皮层及海马的结构遭到破坏,海马CA1区、CA3区更为明显;出现空间学习记忆障碍,具体表现为空间学习能力、空间记忆保持能力及再学习能力下降,学习过程延长。针刺可以改善上述情况,提高MID大鼠空间学习记忆能力。结论针刺通过减轻皮层、海马的损伤保护脑细胞,从而提高MID大鼠空间学习记忆能力。
Objective To investigate the improving effect of acupuncture on spatial learning and memory in rats with multiple infarcted dementia（MID）. Methods A model of MID was made by an injection of thrombus through external carotid retrocatheterism. Changes in spatial learning and memory were determined by Morris water maze. Morphological changes in the cortex and hippocampus were observed by HE staining. Results In MID rats, the cortical and hippocampal structures were destroyed, which was more marked in hippocampal areas CA1 and CA3 ; disorders of spatial learning and memory occurred and they were manifested in poor abilities in spatial learning, memory maintenance and relearning, and prolongation of the learning course. Acupuncture could ameliorate the above conditions and improve MID rat＇s abilities in spatial learning and memory. Conclusion Acupuncture improves MID rat＇s abilities in spatial learning and memory by reducing cortical and hippocampal injury to protect brain cells.
出处
《上海针灸杂志》
2006年第10期44-47,共4页
Shanghai Journal of Acupuncture and Moxibustion
基金
国家自然科学基金资助项目(30472242)
关键词
多发梗塞痴呆
Morris水迷官
学习记忆
针刺
Multiple infarcted dementia
Morris water maze
Learning and memory
Acupuncture
