结缔组织生长因子及其在心血管疾病中的作用

Connective Tissue Growth Factor and its Role in Cardiovascular Diseases

结缔组织生长因子(CTGF)是一种新近发现的细胞因子,是即刻早期基因CCN(CTGF,Cyr61,Nov)家族的成员之一,具有重要的生物学功能。其表达受很多因素调节,参与多种生理及病理过程。研究表明,其在动脉粥样硬化、心肌梗死、高血压等心血管疾病的发生、发展中有重要作用,涉及了多条信号通路,有望成为一些疾病的治疗靶点。

Connective growth factor is a new found eytokine, which is one of the gene family called immediate early gene, having great important biological function. Its expression is regulated by many factors and participates in many physiological and pathological process. Recent studies have demonstrated that CTGF is involved in the occurrence and development of many cardiovascular diseases, such as atherosclerosis, myocardial infarction, hypertension and so on, in which multi-pathway are involved. So it will be the therapeutic target of some diseases in future.