基于Monte Carlo模型的微型PLGA给药系统建模及仿真

Modeling and Simulation of the Drug Release from PLGA Drug Delivery Micro-system Based on Monte Carlo model

多腔体的微型可降解高分子聚合物PLGA药物缓释系统是一种新型植入式给药微器件,其载体结构是结合药物释放的要求和高分子聚合物生物降解特性进行设计并利用MEMS工艺制备.为了解微型给药系统实际释药的性能,需要对其进行建模和仿真研究.基于体溶蚀的MonteCarlo溶蚀模型,建立了具有多腔体的微型PLGA给药载体的释药模型,并对腔体结构为圆形的微型给药系统进行了释药过程仿真.仿真结果表明本文建立的微系统释药模型可以较为准确的描述微系统的释药过程,仿真模型对进一步开发微型PLGA给药系统有重要的参考价值.

The biodegradable PLGA controlled drug delivery system with large array of micro chambers is a new type drug delivery micro device. The structure of the micro-system is designed combining the drug release condition and the biodegradable characteristic of the polymer and fabricated using the MEMS technology. A mathematical model is developed for the PLGA controlled drug delivery system with large array of micro chambers base on Monte Carlo bulk erosion model and numerical simulations are conducted to the drug release from the micro device with round shape micro chambers. The simulation results indicate that the mathematical model can be used to analyze the biodegradation and the controlled release process and the model is very important for the research and development of the PLGA controlled drug delivery micro-system.