原发性高血压患者颈动脉粥样硬化与血尿酸及C反应蛋白的关系探讨

The relationship among serum uric acid,C-reactive protein and the degree of carotid artery atherosclerosis in patients with essential hypertension

目的探讨原发性高血压患者颈动脉粥样硬化程度与血尿酸及C反应蛋白(CRP)的关系。方法将122例原发性高血压患者按颈动脉硬化程度分为内中膜增厚组、斑块形成组和管腔狭窄组,分别测定其与34例正常内膜对照组的血尿酸及CRP的浓度,观察颈动脉粥样硬化程度与血尿酸及CRP的关系。结果斑块形成组和管腔狭窄组的血尿酸及CRP的浓度显著高于内中膜增厚组及对照组(P<0.05)。结论血尿酸及CRP与原发性高血压患者的颈动脉粥样硬化程度有关。

Objective To approach the relationship among serum uric acid, C- reactive protein and the degree of carotid artery atherosclerosis in patients with essential hypertension. Methods 122 patients with essential hypertension were divided into intimamedia thickness group, plaque development group and vessel stenosis group. Concentrations of serum uric acid and C- reactive protein were measured in each patient and in 34 control subjects. The relationship between the degree of carotid artery atherosclerosis and serum uric acid, C- reactive protein was observed. Results The concentration of serum uric acid and C- reactive protein in plaque development group and vessel stenosis group were positively connected with pathologic changes of carotid artery atherosclerosis （ P 〈 0.05）. Conclusion The concentration of serum uric acid and C- reactive protein have a positive relation to the degree of carotid artery atherosclerosis in patients with essential hypertension.