潘生丁对不同程度缺血心脏的作用

Effects of Dipyridamole on Different Degrces of Ischcmic Heart

作者在21条急性开胸犬上,以微米狭窄器造成冠状动脉左旋支不同程度的狭窄.分别在轻度狭窄和临界狭窄基础上,静脉给予潘生丁(0.56mg/kg,注射4min)。用创伤性方法检测用药前后左心室收缩功能的改变,轻度狭窄时,给予潘生丁后,左室舒张压降低22％,冠脉血流量、室内压最大上升速率及室内压最大下降速率有升高趋势,表明心功得到了改善。临界狭窄时,给予潘生丁后,在室舒张压升高55％,而冠脉血流量、左室收缩压、室内压最大上升速率和室内压最大下降速率分别下降25％,33％,37％和51％,表明心功进一步恶化。本实验可部分解释临床冠心病患者做潘生丁试验所表现的不同结果,并为临床合理使用潘生丁提供了新的依据。

The effects of 0.56 mg/kg dipyridamok on left ventricular systolic function under different degrees of coronary stenosis induced by microconstrictor were examined with invasive methods in 21 open chest dogs. This study suggests that in mfld coronary stenosis, left ventricular diastolic pressure (LVDP) decreased by 22%, and cardiac function improved after dipyridamole was used, and when coronary artery was in critical stenosis and dipyridamolc was indused LVDP in-crease by 55%. In the sametime coronary blood flow, left ventricular systolic pressure , (dp/dt)max and (-dp/df)max teased significantly (dropped by 25%, 33%, 37% and 51% respectively). But it is not suitable for clinical treatments of myocardial ischemia with this dosage(0.56mg/kg). Smaller dosage of dipyridamolc should be used in the treatment of coronary heart diseases.