流行性出血热患者的细胞免疫调节失常

Abnormal Cellular Immunoregulation in Patients with Epidemic Hemorrhagic Fever

用抗人T淋巴细胞单克隆抗体和自发性抑制性T细胞(STs)功能检测法,比较分析了流行性出血热(EHF)患者Ts功能和外周血T细胞亚群数量的变化及其与免疫功能紊乱之间的关系。发现EHF患者病程初期STs功能即明显降低,CD_8^+细胞比例显著增加,CD_4/CD_8比值降低,且STs功能及CD_4/CD_8比值与血清C_3含量及循环免疫复合物阳性率有关;STs功能与CD_8^+细胞比例呈负相关,表明增加的CD_8^+细胞可能主要属于细胞毒性T细胞 上述结果证实EHF患者病程中存着调节性T细胞比例及功能的失常。

A comparative study on the Junction of spontaneous T suppressor cells (STs) and T lymphocytes subsets was made in patients with epidemic nemorrhagic fever(EHF). It was found that in the early stages of the disease the activity of STs was markedly lower than that of controls while the percentage of CD8+ cells increased significantly, which led to the decrease and upsetting of the CD4 /CD8 ratio, and that the ac tivity of STs was inversely related to the proportion of CD8+ cells using linear regression analysis, indicating that the increased CD8+ cells may be mainly belong to cytotoxi T cells. It was also shown that the changes of STs function and CD4 /CD8 ratio were related to the abnormalities of serum Ca level and circulating immune complex. The above results suggest that disturbance of host cellular immunorc-gulation may play an important role in the pathogenesis of EHF.