期刊文献+

镉的心脏毒性 被引量:12

Cardiotoxicity of Cadmium
下载PDF
导出
摘要 镉致动物心脏损伤的机制已有多年的研究,损伤过程包括许多病理学的改变,如心脏组织形态破坏、离子内稳态打破、心电图改变、高血压形成、能量代谢紊乱、心肌收缩力降低等等,并且很有可能是心脏的这一系列损伤导致动物在急性镉中毒的情况下死亡。 The mechanism of cardiotoxicity of cadmium has been researched for many years. Many pathologic changeshave been observed, including the destructive change of myocardium histomorphology, the unbalance of ions in heart, the changes of electrocardiograph, hypertention, the turbulence of metabolism and decline of cardiac muscle cell's contraction etc. Thus, these changes result in the animals' death under the acute cadmium exposure.
出处 《环境与职业医学》 CAS 北大核心 2006年第5期436-439,共4页 Journal of Environmental and Occupational Medicine
关键词 心肌 高血压 心电图 cadmium myocardium hypertention electrocardiogram
  • 相关文献

参考文献41

  • 1Trottier B, Athot J, Ricard Ac, et al. Maternal-fetal distribution of cadmium in the guinea pig following a low dose inhalation exposure[ J ]. Toxicol Lett, 2002, 129( 3 ): 189-197.
  • 2Minami A, Takeda A, Nishibaba D, et al. Cadmium toxicity in synaptic neurotransmission in the brain [ J ]. Brain Res, 2001, 894 ( 2 ): 336-339.
  • 3Szuster-Ciesielska A, Stachura A, Slotwinska M, et al .The inhibitory effect of zinc on cadmium-induced cell apoptosis and reactive oxygen species( ROS )production in cell cultures[ J ].Toxicology, 2000, 145 (2-3): 159-171.
  • 4Endo T, Kimura O, Hatakeyama M, et al .Effects of zinc and copper on cadmium uptake by brush border membrane vesicles [ J ]. Toxicol Lett, 1997, 91(2): 111-120.
  • 5Limaye DA, Shaikh ZA. Cytotoxicity of cadmium and characteristics of its transport in cardiomyocytes [ J ]. Toxicol Appl Pharmacol, 1999, 154( 1 ).' 59-66.
  • 6Manca D, Ricard AC, Trottier B, et al .Studies on lipid peroxidation in rat tissues following administration of low and moderate doses of cadmium chloride[ J ]. Toxicology, 1991,67( 3 ): 303-323.
  • 7Kimura O, Endo T, Sakata M. Comparison of cadmium uptakes from apical and basolateral membranes of LLC-PK1 cells [ J ]. Toxicol Appl Pharmacol, 1996, 137( 2 ):301-306.
  • 8Kopp SJ, Glonek T, Perry HM Jr, et al.Cardiovascular actions of cadmium at environmental exposure levels [ J ]. Science, 1982, 217 (4562): 837-839.
  • 9Jamall IS, Naik M, Sprowls Jj, et al .A comparison of the effects of dietary cadmium on heart and kidney antioxidant enzymes: evidence for the greater vulnerability of the heart to cadmium toxicity [ J ] .J Appl Toxicol, 1989, 9( 5 ): 339-345.
  • 10Sarkar S, Yadav P, Trivedi R, et al. Cadmium-induced lipid peroxidation and the status of the antioxidant system in rat tissues [ J ]. J Trace Elem Med Biol, 1995, 9( 3 ): 144-149.

二级参考文献19

  • 1吴训伟,叶葶葶,金泰廙,孔庆瑚,汪再娟,庄昉成.人群环境镉接触肾功能损害剂量反应关系[J].上海医科大学学报,1997,24(1):41-44. 被引量:6
  • 2[4]Wang R,Wang XT,Wu L,et al. Toxic effects of cadmium and copper on the isolated heart of dogfish shark,Squalus acanthias[J]. J Toxicol Environ Health,1999,57(7):507-519.
  • 3[5]Bers DM,Philipson KD,Langer GA. Cardiac contractility and sarcolemmal cabinding in several cardiac muscle preparations[J]. Am J Physiol,1981,240:H576-H583.
  • 4[7]Grand RT,Perry SV,Weeks RA. The amino acid sequance of the troponin C-like protein(Modulator protein) from bovine uterus[J]. FEBS.1978,92(1):137.
  • 5[8]余旬,吴瑶曼译.生物无机化学入门(苏)[M].北京:科学出版社,1984,25-29.
  • 6Toxicological Profile for Cadmium(updated) [R]. Atlanta: ATSDB., 1999:102-104.
  • 7Staessen JA,Kuznetsova T,Roels HA,et al. Exposure to cadmium and conventional and ambulatory blood pressures in a prospective population study[J]. Public Health and Environmental Exposure to Cadmium Study Group.Am J Hypertens,2000,13(2) : 146-156.
  • 8Pizent A,Jurasovie J,Telisman S. Blood pressure in relation to dietary calcium intake, alcohol consumption, blood lead, and blood cadmium in female nonsmoker[J]. J Trace Elem Med Biol,2001,15(2-3) : 123-130.
  • 9Telisman S, Jurasovic J, Pizent A, et al. Blood pressure in relation to biomarkers of lead,cadmium,copper, zinc, and selenium in men without occupational exposure to metals[J]. Environ Res,2001,87(2) :57-68.
  • 10Crump KS. Calculation of benchmark doses from continuous data[J]. Risk Anal, 1995,15:79-89.

共引文献22

同被引文献139

引证文献12

二级引证文献22

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部