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大鼠急性心肌缺血动物实验模型的改进 被引量:3

Improved Method of Acute Myocardial Ischemic Rat Model
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摘要 目的改进大鼠急性心肌缺血动物实验模型时,提高手术的成功率和动物成活率。方法比较传统方法与改进方法动物试验的成功率。结果传统方法成功率只有60%,改进方法成功率达到90%以上。结论改进后的方法能大大降低手术难度,减少实验费用,优于传统方法。 Objective To improve the successful rate of operation and the livability in establishing acute myocardial ischemic rat model. Methods The successful rate of animal experiment is compared between traditional method and improved method. Results The successful rate of improved method was 90%, which was much higher than 30% in successful rate of traditional method. Conclusion The improved method may reduce the difficulty of operation remarkably and cut down the experiment expenditure, which is superior to traditional method.
出处 《法医学杂志》 CAS CSCD 2006年第5期321-323,共3页 Journal of Forensic Medicine
基金 国家自然科学基金资助项目(39700167)
关键词 大鼠 心肌缺血 动物实验模型 rat myocardial ischemic model
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  • 1申洪.免疫组织化学染色定量方法研究(Ⅲ)[J].中国组织化学与细胞化学杂志,1995,4(1):89-92. 被引量:398
  • 2施新猷.医学动物实验方法[M].北京:人民卫生出版社,1986..
  • 3Stumpf WE, Sar M, Aumuller G. The heart: a target organ for estrodiol [ J ]. Science, 1977, 196 (4287): 319 - 321.
  • 4Mendelsohn ME, Karas RH. The protective effects of estrogen on the cardiovascular system[J]. N Engl J Med, 1999,340:1801 - 1811.
  • 5Bakir S, Mori T, Durand J, et al. Estrogen - induced vasoprotection is estrogen receptor dependent: evidence from the balloon- injured rat carotid artery model [ J ]. Circulation,2000, 101: 2342 -2344.
  • 6Gardin JM, Wagenknecht LE, Flack J, et al. Relationship of cardiovascular risk factors to echocardiographic left ventricular mass in healthy young black and white adult men and women[J]. Circulation, 1995,92(3): 380-387.
  • 7李德祥.猝死[A].祝家镇.法医病理学第2版[M].北京:人民卫生出版社,2001.340-382.
  • 8Somjen D, Kohen F, Jaffe A, et al. Effect of gonadal steroids and their antagonists on DNA synthesis in human vascular cells[J]. Hypertension, 1998, 32:39-45.
  • 9Dubey RK, Jackson EK, Gillespie DG, et al. Clinically used estrogen differentially inhibit human aortic smooth muscle cell growth and mitogen- activated protein kinase activity [ J ]. Arterioscler Thromb Vasc Biol, 2000, 20:964 -972.
  • 10Tan E, Gurjar MV, Sharma RV, et al. Estrogen receptor gene transfer into bovine aortic endothelial cells induces eNOS gene expression and inhibits cell migration[ J]. Cardiovase Res, 1999, 43: 788 -797.

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  • 1张会欣,张建新,王超,李兰芳,李永辉.氨基胍对局灶性脑缺血诱导大鼠脑神经元凋亡的影响[J].中华麻醉学杂志,2005,25(4):275-277. 被引量:1
  • 2李永辉,张建新,张会欣,李兰芳.氨基胍对局灶性脑缺血大鼠线粒体损伤的影响[J].中国药理学通报,2005,21(12):1501-1504. 被引量:9
  • 3李立萍,张建新,李兰芳,尚涛.氨基胍对内毒素性肺损伤细胞凋亡的影响[J].中国药理学通报,2007,23(1):28-32. 被引量:12
  • 4Xiaoqiao Z, Rong M, Zhigang Y, et at. Protective effect of ulinastatin a- gainst ischemia- reperfusion injury in rat small bowel transplantation [J]. Transplant Proc,2004,36(5) :1564 -1566.
  • 5Letterio JJ, Bottinger EP. TGF - b eta knockout and dora inant - nega- tive receptor transgenic mice[ J]. Miner Electrolyte Metab, 1998,24 : 161 - 167.
  • 6O Callaghan C J, Williams B. Mechanical strairr induced extracellular matrix production by human vascular smooth muscle cells: role of 13l [ J]. Hypertension ,2000,36:319 - 324.
  • 7张建新,李兰芳,张会欣,李永辉.氨基胍对大鼠局灶性脑缺血损伤后TNF-α、IL-1β及细胞凋亡的作用[J].中国病理生理杂志,2007,23(11):2151-2154. 被引量:7
  • 8Olivetti G, Quaini F, Sala R, et al. Acute myocardial infarction in humans is associated with activation of programmed myocyte cell deth in the surviving portion of the heart[J]. J Mol Cell Cardiol, 1996,28(9):2005-2016.
  • 9McCintock DS, Santore MT, Lee VY, et al. Bcl-2 family members and funetioual electron transport chain regulate oxygen deprivation- induced cell death[J]. Mol Cell Biol, 2002, 22( 1 ):94-104.
  • 10Babu PP, Suzuki G, Ono Y, et al. Attenuation of ischemia and/or reperfusion injury during mybcardial infarction using mild hypothermia in rats: an immunohistochemical study of bcl-2, bax, Bak and TUNEL[J]. Pathol Int, 2004, 54(12): 896-903.

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