不同损伤程度脑震荡鼠逆行性遗忘变化比较

Comparison of Retrograde Amnesia Changes within Different Injury Levels of Cerebral Concussion in Rats

目的研究不同损伤程度脑震荡(CC)大鼠逆行性遗忘(RA)之变化情况。方法用金属单摆打击装置复制大鼠不同损伤程度脑震荡模型,用Morris水迷宫检测脑震荡后大鼠逆行性遗忘变化情况。结果单纯性脑震荡(PCC)大鼠打击后72h内出现逆行性遗忘,伤后4d出现认知受损,随后恢复。复杂性脑震荡(CCC)大鼠打击后5d内既有逆行性遗忘的存在,又有认知功能受损,5d后恢复。结论大鼠不同损伤程度脑震荡后均出现逆行性遗忘,且脑震荡损伤程度不同,逆行性遗忘持续时间亦不同,脑震荡程度越重,RA持续时间越长。

Objective To investigate the retrograde amnesia changes within different injury levels of cerebral concussion in rats. Methods A metallic pendulum striker device of brain injury was deployed to duplicate CC models of different injury levels within Stragu-Dawley（S-D） rats. The investigated animals were divided into two groups according to classification standard, that is, Pure Cerebral Concussion （PCC） group and Complicated Cerebral Concussion （CCC） group. One control group was used ,and each group included 8 animals. The retrograde amnesia of each group was assessed by Morris Water Maze （MWM） Test from 3 days preinjury to 7 days postconcussion. Results Compared with the control group, the retrograde amnesia was detected within 3 days in PCC group, and 5 days in CCC group after injury. At the same time, the two groups both manifested space recognition deficit. Conclusion The retrograde amnesia existed in both pure cerebral concussion group and complicated cerebral concussion. Furthermore, the lasting time of retrograde amnesia in animals correlates to the injury level of brain concussion.