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乳腺癌线粒体DNA突变的研究进展 被引量：1

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摘要 目前认为肿瘤的生物学特征不仅取决于核内遗传物质，而且与惟一的核外遗传物质线粒体DNA（mitochondrial DNA，mtDNA）也有一定的关系。各种因素所致的mtDNA损伤（包括突变、表达异常、整合和不稳定性等）与细胞的癌变、肿瘤的发生发展之间可能存在一定的关系。在多种实体性肿瘤中发现了mtDNA突变的报道。
作者 孙玉兰 付丽
机构地区 天津医科大学附属肿瘤医院乳腺病理科教育部乳腺癌研究重点实验室
出处 《中华病理学杂志》 CAS CSCD 北大核心 2006年第10期625-627,共3页 Chinese Journal of Pathology
基金 国家自然科学基金(30470667)
关键词 线粒体DNA突变 乳腺癌 实体性肿瘤 mtDNA损伤 MTDNA突变 遗传物质 生物学特征 表达异常
分类号 R737.9 [医药卫生—肿瘤]
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参考文献25

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二级参考文献14

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中华病理学杂志
2006年 第10期

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