肥胖2型糖尿病患者血清E-选择素水平与氧化应激的关系

Relationship between the E-selectin and oxidative stress in patients with obese type 2 diabetes mellitus

目的:探讨肥胖2型糖尿病(DM)患者血清E-选择素及氧化应激变化的关系。方法:检测肥胖2型DM患者血清E-选择素、氧化低密度脂蛋白胆固醇(ox-LDL)、血清丙二醛(MDA)含量和血清超氧化物歧化酶(SOD)活性。结果:非肥胖和肥胖2型DM患者E-选择素、ox-LDL和MDA含量均显著高于正常对照组(P<0.05),HDL-C、HDL2-C和HDL3-C含量均显著低于正常对照组(P<0.01),肥胖2型DM患者SOD活性显著低于正常对照组(P<0.01)。肥胖2型DM患者的E-选择素和MDA含量均明显高于非肥胖2型DM患者(P<0.05),而SOD活性明显低于2型DM患者(P<0.01)。肥胖2型DM患者E-选择素与HbA1 c、腰围、TC、ox-LDL和MDA正相关(r=0.352,P<0.05;r=0.634,P<0.05;r=0.517,P<0.05;r=0.480,P<0.05;r=0.572,P<0.05),与HDL3-C呈负相关(r=-0.374,P<0.05)。结论:肥胖2型DM患者血清E-选择素含量明显增加,氧化应激可能参与其变化。

AIM： To investigate the relationship between the levels of soluble E - selectin and oxidative stress in patients with obese type 2 diabetes mellitus. METHODS ： The level of E - selectin, the contents of ox - LDL and malondialdehyde （MDA） and activities of superoxide dismutase （SOD） were measured in patients with obese and non -obese type 2 diabetes mellitus. RESULTS ： The levels of E - selectin, ox - LDL and MDA were higher in patients with obese type 2 diabetes mellitus than those in control group （P 〈0.05） , and the contents of HDL- C, HDL2 -C and HDL3 -C were significantly lower than those in control group （P 〈0.01 ）. The activity of SOD in patients with obese type 2 diabetes mellitus was significantly lower than that in control group. The contents of E - selectin and MDA were more markedly elevated in patients with obese type 2 diabetes mellitus than those in patients with non - obese type 2 diabetes mellitus （P 〈0.01 ,P 〈0. 05 ） and the activity of SOD was also signifieantly lower than that in patients with non - obese type 2 diabetes mellitus （ P 〈 0. 01 ）. There was significantly positive correlation between E-selectin and HbAlc, waist circumference, TC, ox- LDL, MDA （r = 0.352, P 〈0.05; r =0.634, P 〈0.05; r =0.517, P 〈0.05; r =0.480, P 〈0.05; r =0.572, P 〈0.05）, and negatively correlation between E - selectin and HDL3 - C （ r = - 0. 374, P 〈 0. 05 ）. CONCLUSION： The plasma level of E - selectin is markedly elevated in patients with obese type 2 diabetes mellitus. E - selectin is possibly associated with oxidative stress.