联合使用白细胞滤器和抑肽酶对机体的保护作用

Protection Effect of Combination of Leukocyte Depletion and Aprotinin

体外循环中,炎性反应和凝血反应同时被激活,这可能是导致灌注后炎性反应综合征的主要原因。白细胞滤器能够减少循环中白细胞,抑制炎性反应,但由于炎性反应和凝血反应存在密切关系,其对血液的保护作用受到限制。抑肽酶是一种丝氨酸蛋白抑制剂,能抑制纤溶酶活性,保护血小板功能,但其抗炎作用弱,对器官的保护作用仍不肯定。体外循环中联合使用白细胞滤器和抑肽酶能够同时抑制炎性反应和凝血反应,可能对机体发挥更好的保护作用。

There is a close relationship between inflammation and coagulation response. Inflammation and coagulation are activated simultaneously during cardiopulmonary bypass, which induce postperfusion syndrome. Leukocyte depletion filter can inhibit inflammation by reducing neutrophils in circulation. But, its effects on blood conservation are limited. Aprotinin is a serine protease inhibitor, and can prevent postoperative bleeding by anti-fibrinolysis and protection of platelet function. But its effects on anti-inflammation and protection of organs are subjected to be doubted. The combination of leukocyte depletion filter and aprotinin can inhibit inflammation as well as regulate coagulation, and may exert a good protective action during cardiopulmonary bypass.