CD105和VEGF、TGF-B1在结直肠癌的表达及其与浸润、转移和血管生成的关系

Expression of CD105,VEGF and TGF-β1 in colorectal cancer and their relationship to invasion,metastasis and angiogenesis

目的探讨结直肠癌中CD 105和VEGF、TGF-β1的表达及与血管生成的关系。方法应用免疫组化方法检测60例结直肠癌中CD 105标记的微血管密度(M VD)和VEGF、TGF-β1的表达。结果60例结直肠癌中CD 105表达的M VD为36.50±9.43。VEGF、TGF-β1表达的阳性率为68.3%,75.0%。M VD和VEGF、TGF-β1表达与肿瘤浸润深度、淋巴结转移和Dukes分期密切相关(P<0.05)。VEGF、TGF-β1表达均与M VD呈正相关(P<0.01),TGF-β1与VEGF也呈正相关(P<0.05)。结论CD 105、VEGF、TGF-β1关系密切,三者联合检测可作为结直肠癌新生血管和浸润转移的有价值的标志物。

Objective To study the expression of CD105,VEGF and TGF-β1 in colorectal cancer and their relationship with angiogenesis. Methods Immunohistochemical staining （S-P method） for VEGF, TGF-β1 and microvessel density （MVD） with marked CD105 were performed in 60 cases of colorectal cancer. Results The value of MVD with marked CD105 was 36.50±9.43 in colorectal cancer. The positive rates of VEGF and TGF-β1 were 68.30/00 and 75.0% ,respectively. The value of MVD and the expression of VEGF and TGF-β1 were significantly correlated to the tumor depth of invasion, lymphonode metastasis and Dukes stages （P〈0.05）. The expression of VEGF and TGF-β1 was positively correlated to MVD （P〈0.01）. There was a significant positive correlation between the expressions of TGF-β1 and VEGF（P〈0.05）. Conclusion CD105, VEGF and TGF-β1 are closely correlated,which may be valuable markers in evaluating the angiogenesis,invasion and metastasis in colorectal cancer when combined.