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11q22-q25区候选抑癌基因OPCML、POU2F3、CUL-5启动子CpG岛甲基化与子宫颈癌的发生 被引量：2

Promoter CpG islands methylation of OPCML，POU2F3 and CUL-5 in cervical cancer
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摘要 目的研究11q22-q25区候选抑癌基因OPCM L、POU 2F 3、CUL-5启动子CpG岛甲基化和子宫颈癌的发生。方法以甲基化特异性PCR(M SP)检测子宫颈正常组织和癌组织中OPCM L、POU 2F 3、CUL-5启动子CpG岛甲基化。结果16例子宫颈正常组织中均未检测到OPCM L、POU 2F 3、CUL-5启动子CpG岛甲基化;63.9%(23/36)子宫颈癌组织中存在OPCM L甲基化,但未检测到POU 2F 3、CUL-5甲基化。结论OPCM L在子宫颈癌中存在高度的启动子CpG岛甲基化,其可能为子宫颈癌相关候选抑癌基因。
作者 张松法 叶枫 陈怀增 吕卫国 谢幸
机构地区 浙江大学医学院附属妇产科医院
出处 《实用肿瘤杂志》 CAS 2006年第5期440-442,共3页 Journal of Practical Oncology
基金 浙江省自然科学基金项目(Y205190)
关键词 宫颈肿瘤 基因 抑制 肿瘤 启动区(遗传学) 甲基化
分类号 R737.33 [医药卫生—肿瘤]
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参考文献10

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二级参考文献10

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实用肿瘤杂志
2006年 第5期

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