阿糖胞苷纳米粒的制备及其释药规律研究

Preparation of Cytarabine Nanoparticle and Study on the Drug Releasing Mechanism

采用乳化聚合法制备阿糖胞苷纳米粒,研究其体内外释药特性。结果表明阿糖胞苷纳米粒体外释药规律符合双指数方程,有明显的缓释作用。在家兔体内的药物动力学过程符合二室模型,与阿糖胞苷注射剂相比,t1/2β和M RT延长,CL降低,表明阿糖胞苷纳米粒可显著延长阿糖胞苷在体内存留时间,具有明显的缓释特征。

Cytarabine nanoparticle was prepared through emulsion polymerization method, and its releasing properties were studied. The results showed that releasing principle complied with biexponential equation and had characteristics of sustained releasing. The pharmacokinetics in rabbits complied with two-department model. Compared with cytarabine injection, cytarabine nanoparticle had prolonged t1/2β and MRT and reduced CL, which showed nanoparticle could significantly prolong the retention time of Ara-C and possess significant sustained releasing character.