海绵窦侵袭性垂体瘤Ki67、PCNA、p53、c-erB-2的免疫组化研究

Immunohistochemical study on Ki67,PCNA,p53,c-erB-2 in pituitary adenomas invading cavernous sinus

目的研究Ki67、PCNA、p53、c-erB-2与海绵窦侵袭性垂体瘤发生、侵袭性及预后的关系。方法采用S-P免疫组化法检测22例海绵窦侵袭性垂体瘤、32例非侵袭性垂体瘤Ki67、PCNA、p53、c- erB-2的表达。结果Ki67、PCNA、c-erB-2在海绵窦侵袭性垂体瘤中的表达阳性率明显高于非侵袭性垂体瘤(P＜0．01)。结论Ki67、PCNA及C-erb-2均参与了海绵窦侵袭性垂体瘤的发生,联合检测有助于判断垂体腺瘤侵袭性和预后。

Objective To study the role of Ki67,PCNA,p53,c-erB-2 in oncogenesis and prognosis of pituitary adenomas invading cavernous sinus. Methods S-P immunohistochemical staining technique was used to detect the expression of Ki67,PCNA,p53,c-erB-2 in 22 cases of pituitary adenomas invading cavernous sinus and in 32 cases of noninvasive pituitary adenomas,Results The expression of Ki67, PCNA,c-erB-2 in pituitary adenomas invading cavernous sinus was much higher than in noninvasive pituitary adenomas （P〈0.01）.Conelusion Ki67,PCNA and e-erB-2 may be correlated with the oncogenesis and prognosis of pituitary adenomas invading cavernous sinus.