单次大剂量重组人干扰素α-1b对成人水痘病程的影响

Effect on the Course of Varicella in Adult Treated by Once Large Dose Interferonα1 b

目的探讨单次大剂量重组人干扰素-α1b(IFNα-1b)对成人水痘病程的影响。方法患者随机分为两组。观察组除口服阿昔洛韦(ACV)外,单次肌肉注射IFNα-1b 300万u;对照组除口服ACV外,单次肌肉注射维生素B1。记录患者水疱结痂时间和痊愈时间。结果观察组在结痂时间和痊愈时间上均少于对照组,差异均有显著性(P<0.01)。结论早期应用单次大剂量IFNα-1b可缩短成人水痘病程。

Objective To evaluate the clinical efficacy on the course on varicella in adult treated by once large dose interferon α1b（IFNα-1b）. Methods The patients were divided into two groups randomly, The patients of research group were prescribed acyclovir and IFNα-1b. And the patients of control group were prescribed acyclovir and vitamin B1. Times of scabbing and healing were recorded. They were analyzed statistically. Results Time of scabbing and healing in research group was not so long as that in control group. The result showed extraordinary difference statistically（P 〈 0.01 ）. Conclusion The course of varicella in adult may be shortened while IFNα-1b be prescribed at an early stage.