幽门弯曲菌致病机理的病理学观察

Pathological Observations of Pathogenic Mechanism by Campylobacter Pylori

作者对120例主诉有上消化道症状的患者,经胃纤维镜观察并钳取胃窦或胃体粘膜活检标本,常规石蜡切片,HE、肥大细胞、Gomori银染法染色,光镜观察。结果表明:Campylobacter pylori感染与慢性活动性胃炎、慢性萎缩性胃炎关系密切;在120例中,C.pylori检出率为57.5％。同时还发现中性粒细胞渗出较多的部位,细菌数量很少或没有;反之亦然。作者就此对其发病机理作了初步探讨。

The biopsics of mucosa were taken from pyloric sinus and from gastric body by fibrous gastroenteroscopy in 120 cases with the chief symptoms of upper digestive tract. The specimcns were fixed in formalin, prepared with paraffin sections and stained by HE, mast cells and Gomori silver stainings.The results showed that the infection of C. pylori was closely related to chronic active gastritis and chronic atrophic gastritis. In 120 cases, the rate of positive C. pylori was 57.5%. The places with marked leukocytic infiltration contained only a few amount or even none of C. pylori, on the contrary, the places with numerous C. pylori manifested slight or no leukocytic infiltration. The authors consider that this phenomenon might be the elimination of C. pylori by leukocytes in company with the simultaneous injury of tissues and cells.