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食管癌组织中微血管密度与转移关系的研究

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摘要 目的 探讨食管鳞癌组织内微血管分布规律与癌组织分化程度、食管旁淋巴结转移的关系以及微血管临床病理价值,为寻找预测和治疗食管癌的新方法提供依据。方法 37例食管癌标本,每例切片先用40倍光镜扫视寻找血管高密度区,随机计数20个视野(200倍光镜下)的微血管,然后求平均值。结果 早期鳞癌微血管计数明显低于中晚期鳞癌的微血管计数,两者相比存在极显著性差异(P〈0.001)。结论 肿瘤的血管生成促使肿瘤的体积增加,肿瘤边缘部位的肿瘤细胞容易通过静脉-淋巴结吻合处,从血液循环进入淋巴管,因此肿瘤血管生成对淋巴结转移具有间接的促进作用。所以微血管的密度可以作为判断和预测恶性肿瘤的潜在性转移或复发的重要指标。
出处 《卫生职业教育》 2006年第20期132-133,共2页 HEALTH VOCATIONAL EDUCATION
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