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子痫前期患者脐血和胎盘组织中IGF-Ⅱ检测的临床意义 被引量：3

The clinical significance of detecting IGF-Ⅱ in umbilical serum and placenta in patients with preeclampsia
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摘要 目的:探讨IGF-Ⅱ在子痫前期发病机制中的作用。方法:用免疫组织化学方法检测正常晚孕组和轻度、重度子痫前期患者胎盘组织中IGF-Ⅱ的表达,同时用ELISA方法检测3组研究对象胎儿脐血中IGF-Ⅱ的含量。结果:IGF-Ⅱ在脐血中的含量,重度子痫前期组显著高于轻度子痫前期组(P<0.001),轻度子痫前期组显著高于正常晚孕组(P<0.01);IGF-Ⅱ在胎盘组织中的表达,重度子痫前期组显著低于轻度子痫前期组(P<0.01),轻度子痫前期组显著低于正常晚孕组(P<0.01)。结论:子痫前期时脐血IGF-Ⅱ含量升高可能是子痫前期病理变化的结果,而胎盘组织中IGF-Ⅱ表达减少可能是引发子痫前期的重要因素之一。 Objective： To explore the effect of insulin - like growth factor - Ⅱ （IGF - Ⅱ ） on the pathogenesis of preeclampsia. Methods： The umbilical serum IGF - Ⅱ levels in twenty one normal pregnancy and ninety - tree preeclamptic patients was detected by ELISA ; The expression of IGF - Ⅱ in placental tissue was measured by immunohistochemistry SP. Results： The content of IGF - Ⅱ in umbilical serum was significantly higher in severe preeclampsia group than that of mild preeclampsia group （ P 〈0. 001 ） and that of mild preeclampsia group were obviously higher than that of normal pregnancy group （ P 〈 0. 01 ） ; The expression of IGF - Ⅱ in severe pregnancy placentas were obviouslyly lower than that of mild preeclampsia group （ P 〈 0. 01 ） and both were significantly lower than that of normal group （ P 〈0. 01 ） . Conclusion： The [GF - Ⅱ level in placentas could be a key factor involved in the pathogenesis of preeclampsia; and the content of IGF - II in umbilical serum could be the result of pathogenesis of preeclampsia.
作者 常彩红 牛德亮 张展 贾莉婷
机构地区 郑州大学第三附属医院检验科 河南中医学院第一附属医院检验科
出处 《中国妇幼保健》 CAS 北大核心 2006年第20期2849-2851,共3页 Maternal and Child Health Care of China
关键词 子痫前期 脐血 胎盘组织 胰岛素生长因子-Ⅱ Preeclampsia Umbilical Placenta IGF- Ⅱ
分类号 R714.245 [医药卫生—妇产科学]
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参考文献9

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同被引文献34

  • 1王晓春,肖平,刘惠宁,黄顺玲,陈卫群,吴佳捷.母血、羊水中IGF水平与胎儿宫内生长受限关系的研究[J].实用预防医学,2004,11(5):892-893. 被引量：4
  • 2Ning Y, Williams M A, Vadachkoria S, et al. Maternal plasma concentrations of insulinlike growth factor-1 and insulinlike growth factor-binding protein 1 in early pregnancy and subsequent risk of preectampsia[J]. Clin Biochem, 2004, 37 (11) :968-973.
  • 3Chakraborty C, Gleeson L M, McKinnon T, et al. Regulation of human trophoblast migration and invasiveness [J]. Can J Physiol Pharmacol,2002,80(2) : 116-124.
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  • 5BauerMK, Breier BB, Bloomfield FH, et al. Chronic pulsatile infusion- ofgrowth hormone to growth - restricted fetal sheep increases circula - ting fetal insulin -like growth factor - 1 levelsbutnot fetalgrowth [ J ]. J Endocrinol,2003,177 ( 1 ) :83 - 92.
  • 6褚冬梅,等.检测妊娠期高血压疾病孕妇血清中胰岛素样生长因子-Ⅰ浓度的临床意义[D].吉林大学硕士论文.
  • 7BabaM, Sibai. Diagnosis andmanagementofgestation hypertension andpreeclampsia[ J]. Obstet Gynecol,2003,102 ( 1 ) :181 - 182.
  • 8Sabine Mutze, Sabine Rudnik - Schoneborn, Klaus Zerres, et al. Genes and the preeclampsia Syndrome[ J]. Perinat Med ,2008,36:38 - 58.
  • 9Ergaz Z, Avqil M, Ornov A. Intrauterine growth restriction- etiology and consequences: what do we know about the human situation and experimental animal models? [ J ]. Reprod Toxico1,2005,20 ( 3 ) : 301 - 322.
  • 10Gupta S, Agarwal A, Sharma RK. The role of placental oxidative stress and lipid peroxidation in preeclampsia [ J ]. Obstet Gynecol Surv ,2005,60:807 - 816.

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中国妇幼保健
2006年 第20期

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