毛细支气管炎激素吸入治疗预防哮喘的研究

The theraputic effect of glucocorticoids inhalation on preventing infant asthma after bronchiolitis

目的：观察毛细支气管炎患儿采用激素吸入治疗预防婴幼儿哮喘的疗效。方法：将毛细支气管炎患儿随机分为两组。观察组（54例）以丙酸氟替譬松吸入治疗，急性期每日2次，每次1揿（125μg），出院后每日早晨1次，每次1揿（125μg）．连续半年；对照组（50例）未作激素吸入治疗．两组患儿出院后随访8-15个月。结果：观察组喘息发作14例（14／52），占26．92％，对照组22例（22／47），占46．80％，两组比较差异有显著性（P〈0．05）；观察组转为婴儿哮喘7例（7／52），占13．46％，对照组15例（15／47）．占31．91％．两组比较差异有显著性（P〈0．05）。结论：毛细支气管炎患儿给予激素吸入治疗，可显著减少喘息发作和降低婴幼儿哮喘的发生率，值得临床推广应用。

Objective： To evaluate the theraputic effect of glucocorticoids inhalation on preventing infant asthma after bronchiolitis. Methods： 104 infants were randomly divided into experimental group （54 cases, received fluticasone inhalation twice a day during infectious period, the dose of each time 125 μg, after out of clinical therapy period, it should be given for half a year, only once 125 μg every morning） . The control group was received nothing. These cases were followed up for 8 - 15 months. Results： 14 cases in experimental group （ 14/52, 26. 9% ） and 22 cases in control group （22/47, 46. 8% ） took place gasp. There was significant difference between the two groups （ P 〈0. 05） . 7 cases in experimental group （7/52, 13. 5% ） and 15 cases in control group （ 15/47, 31.9% ） developed into infant asthma The differences between them were very significant （P 〈 0.05） . Conclusion： The glucocorticoids inhalation treating can significantly reduce gasp and asthma after bronchiolitis. So it deserves to be performed in more patients.