羊膜腔灌注治疗重度子痫前期围生儿的结局分析

Analysis of perinatal results of fetal growth restriction by amniotic infusion therapy

目的：探讨重度子痫前期围生儿经介入超声羊膜腔内治疗的结局分析。方法：对1999年5月-2004年5月分娩的95例孕28-34周重度子痫前期的孕妇的临床资料进行回顾性分析，治疗组（58例）行B超介入下羊膜腔内灌注药物治疗1～2次，与对照组（37例）进行对比分析围生儿结局。结果：治疗组行介入超声穿刺均成功，未发生羊膜腔内输液并发症，早产儿Apgar评分1min与5min均高于对照组（均P〈0．01），国产儿存活率达98．28％，ARDS发生率低于对照组（P〈0．05）。结论：重度子痫前期的孕妇在期待治疗中行羊膜腔内灌注术能明显降低围生儿的病死率，是一项安全、有效的方法。

Objective： To explore, the perinatal results of severe preeclampsia by amniotic infusion therapy. Methods： A retrospective study of 95 patients with severe preeclampsia during 28 to 34 weeks pregnancy in this hospital from May 1999 to May 2004 was made. Therapy group （58 cases） received intravenous infusion, the perinatal outcome were compared as controls （37 cases） . Results： Ultrasound guided amnioinfusion were all successful in therapy group, there was no maternal complication. Statistical difference was found in premature infant Apgar score between therapy group and control group. The incidence of ARDS was 3. 4% , whereas that of the control group was 35. 1% （P 〈 0. 01 ） . Conclusion： Interventional uhrasonography amnioinfusion is a safe, reliable therapeutic method in severe preeclampsia. It may reduce perinatal morbidity.