摘要
研究了一种新的制作多孔可生物降解聚合物支架的方法，该方法用碳酸氢钠／碳酸钠（NaHCO3／NazCO3）粒子作造孔剂，跟盐酸反应进行发泡。支架的孔隙率随着造孔剂与聚合物的质量比增加而增大，孔的尺寸随着造孔剂尺寸的增大而增大，通过控制造孔剂粒子的尺寸和用量，可以很容易地控制聚合物支架的孔结构。支架孔隙率高达94．8％，大孔的尺寸范围为100-400μm，并具有均匀的互相连通的开放的孔墙结构，有利于细胞和组织的生长。用该方法制作的支架比传统的盐沥滤法制作的支架，孔隙更多，分布均匀，大孔更多，孔墙结构互相连通、开放。
A new method of fabricating porous scaffolds composed of biodegradable polymer was developed, using Na2CO3/NaHCO3 particulates as pore-forming material to foam by reacting with hydrochloric acid. The pore structures of polymer scaffolds can easily be manipulated by controlling the size and mass fraction of Na2CO3/NaHCO3 particulates. The scaffolds are highly porous with porosity greater than 90%, with larger pore size ranging from 100 μm to 400 μm, and with the well distributed, interconnected and open pore wall structure necessary for tissue engineering. The scaffold fabricated by the method has more and better distributed pores, has interconnected pore wall structures, and there are more big pores comparing with the one fabricated by conventional salt leaching method.
出处
《粉末冶金材料科学与工程》
EI
2006年第5期310-314,共5页
Materials Science and Engineering of Powder Metallurgy
关键词
组织工程
可生物降解的聚合物
支架
制作
tissue engineering
biodegradable polymer
scaffold, fabrication
