所谓肺硬化性血管瘤组织中p53和PCNA蛋白表达及意义

Expression of p53 and PCNA in So-called Pulmonary Sclerosing Hemangioma and Its Significance

目的:探讨p53及PCNA蛋白在所谓肺硬化性血管瘤(so-ca lled pu lm onary scleros ing hem ang iom a,PSH)组织中的表达及意义。方法:应用免疫组化S-P法,检测35例PSH、8例肺炎性假瘤(pu lm onary pseudotum or,PP)、8例正常肺组织(norm a l lung tissue,NL)中p53和PCNA的蛋白表达。结果:p53及PCNA蛋白在35例PSH组织中的阳性表达率分别为45.71%(16/35)和62.86%(22/35),在8例PP组织中的阳性表达率分别为0%(0/8)和25%(2/8),而8例NL组织中均呈阴性表达。p53、PCNA在PSH组织的阳性表达率显著高于NL和PP组织(P<0.05)。结论:p53、PCNA蛋白的过表达可能与PSH发生发展有关。

Objective：To examine the expression of p53 and PCNA in so-called pulmonary sclerosing hemangioma （PSH）. Methods：Immunohistochemical method was used to examine the sections from 35 cases of so-called PSH,8 pulmonary pseudotumors（PP）and 8 normal lung tissues（NL）. Results ;The positive ratios of p53 and PCNA were 45.71% （16/35）and 62.86% （22/35）in 35 cases of PSH, respectively and were 0% （0/8）and 25 % （2/8）in 8 PP ,but there was no expression in 8 NL. The positive ratio of p53 protein,PCNA was significantly higher in PSH than in NL and PP（P〈 0.05）. Conclusions：The overexpression of p53,PCNA may involve in genesis and development of PSH.