摘要
目的:探讨p53及PCNA蛋白在所谓肺硬化性血管瘤(so-ca lled pu lm onary scleros ing hem ang iom a,PSH)组织中的表达及意义。方法:应用免疫组化S-P法,检测35例PSH、8例肺炎性假瘤(pu lm onary pseudotum or,PP)、8例正常肺组织(norm a l lung tissue,NL)中p53和PCNA的蛋白表达。结果:p53及PCNA蛋白在35例PSH组织中的阳性表达率分别为45.71%(16/35)和62.86%(22/35),在8例PP组织中的阳性表达率分别为0%(0/8)和25%(2/8),而8例NL组织中均呈阴性表达。p53、PCNA在PSH组织的阳性表达率显著高于NL和PP组织(P<0.05)。结论:p53、PCNA蛋白的过表达可能与PSH发生发展有关。
Objective:To examine the expression of p53 and PCNA in so-called pulmonary sclerosing hemangioma (PSH). Methods:Immunohistochemical method was used to examine the sections from 35 cases of so-called PSH,8 pulmonary pseudotumors(PP)and 8 normal lung tissues(NL). Results ;The positive ratios of p53 and PCNA were 45.71% (16/35)and 62.86% (22/35)in 35 cases of PSH, respectively and were 0% (0/8)and 25 % (2/8)in 8 PP ,but there was no expression in 8 NL. The positive ratio of p53 protein,PCNA was significantly higher in PSH than in NL and PP(P〈 0.05). Conclusions:The overexpression of p53,PCNA may involve in genesis and development of PSH.
出处
《中国误诊学杂志》
CAS
2006年第20期3898-3900,共3页
Chinese Journal of Misdiagnostics