眼眶NK/T细胞淋巴瘤误诊2例分析并文献复习

Literature Review of Orbital Natural Killer/T-Cell Lymphoma and Two Cases Reports

目的:综述眼眶NK/T细胞淋巴瘤的临床诊断、治疗及常见误诊原因。方法:结合文献和2例个案,对眼眶NK/T细胞的临床诊断、治疗及鉴别诊断进行分析。结果:眼眶NK/T细胞淋巴瘤是临床罕见的一类结外淋巴瘤,易误诊为眼结膜炎、眼非特异性炎症、眼眶周围软组织炎或蜂窝织炎。病理改变、免疫表型符合鼻型NK/T细胞淋巴瘤。结论:眼眶NK/T细胞淋巴瘤临床表现、免疫表型、影像学特征独特,容易误诊,临床进展快,死亡率高。

objective：To analyze the clinical manifestation,diagnosis,mis-diagnostic reasons and treatment method of orbital NK/T cell lymphoma. Methods ：The literature was reviewed and 2 patients with orbital NK/T cell lymphoma were collected. Then we analyzed the diagnosis,differential diagnosis and therapy of orbital N K/T cell lymphoma. Results：Orbital NK/T cell lymphoma was one kind of relatively rare,new reported extra-nodal lymphoma,which was usually mis-diagnosed as conjunctivitis ,idiopathic orbital inflammation ,periorbital area inflammation. The orbital NK/T cell lymphoma and nasal NK/T cell lymphoma shared similar stopathology,immunopathology. Conclusions ：The orbital NK/ T cell lymphoma shows distinctive cliniopathologic,immunophenotypic and characteristic CT or MRI manifestations. The patients are diagnosed difficultly in the early stage,presented highly aggressive clinic course and a very high lethality.