摘要
本文报道尼卡地平对大鼠血小板聚集功能的影响。体内与体外的实验结果都表明尼卡地平能增强ADP诱导的血小板聚集反应。
Nicardipine(NC)has been used for the treatment of coronary heart disease. In this article the effect of NC on rat platelet aggregation was studied.
The results showed that NC at a dose of 2.7mg/Kg and 10.8mg/Kg ip once daily for 7 days could potentiate ADP-induced rat platelet aggregation in vivo. When the concentration of NC was 2.7mg/Kg the increased rates of platelet aggregation within 1 and 5 min were -0.40% and 14.10% respectively. However if the concentration was changed to 10.80mg/Kg the increased rates were 51.90% and 45-50% respectively. In vivo the enhancing effect of NC on rat platelet aggregation was also observed. When NC was added with a final concentration of 200 μmol/L, the rates of platelet aggregation within 1 and 5 min increased to 0.19% and 1.70% respectively, While with the final concentration of 400μmol/L the rates increased within 1 and 5 min to 28.90% and 20.20%.
出处
《第一军医大学学报》
CSCD
1990年第2期171-173,共3页
Journal of First Military Medical University