离子液体快速促进合成N-芳亚甲基-4-氨基安替比林

Synthesis of N-arylidene-4-aminoantipyrine promoted by ionic liquid

离子液体能有效地在室温条件下促进一系列芳醛与4-氨基安替比林反应,以73%～94%产率生成相应的席夫碱.该法反应条件温和,反应速度快,后处理简单方便,产率高,离子液体可以重复使用,对环境友好.

The ionic liquid 1-butyl-3-methylimmidazohum tetrafluoroborate （ [ bmim] BF4 ） efficiently promoted synthesis of a variety of N-arylidene-4-aminoantipyrines from corresponding aromatic aldehydes and 4-aminoantipyrine at room temperature, and the yield was up to 73% -94% .The present protocol offers several advantages including mild conditions, high yields, short reaction time, simple work-up procedure. Moreover, the ionic liquid can be reused, and it is benign to environment.