脱脂大米胚芽降脂减肥作用研究

Study on the Preventive Effect of Defated Rice-germ to Obesity and Hyperlipidemia

目的:探讨脱脂大米胚芽对大鼠肥胖及高血脂的预防性作用。方法:将50只大鼠按血清总胆固醇(TC)水平随机分为阴性对照组、肥胖模型组和3个添加不同剂量的脱脂大米胚芽组20、100、300mg/kgbw。每周称重1次,第5周末断头取血,测TC、TG和HDL-C;剥离肾及睾丸周围脂肪并称重。结果:肥胖模型组与阴性对照组相比,大鼠体重、体脂比、TC、TG水平显著增加;3个脱脂大米胚芽添加组大鼠体重、体脂比、TC、TG水平均低于肥胖模型组,且有显著性或极显著性差异。结论:脱脂大米胚芽能够预防大鼠肥胖及高脂血症的形成。

Objective： To explore the effect of Defated Rice-germ（DRG） on obesity and hyperlipidemia. Methods： 50 rats were divided into 5 groups randomly according to the level of TC. They were fed with one of the following diets： basal - diet（BD）, high-fat-diet（HFD） and high-fat-diet with different dosages of DRG（ 20, 100, 300mg/kg bw）. All rats were weighted once a week. By the end of the 5th week,the animals were sacrificed and the serum levels of TC, TG, HDL-C were tested and the fat pad around the kidneys and the testicles were dissected off and weighted. Results： The average body weight（bw）, the ratio of body fat and BW, the serum levels of TC, TG of the HFD group were significantly higher than those of the BD group. But the average BW, the ratio of body fat and BW, the serum levels of TC,TG of the groups supplemented with dosages of DRG were significantly lower than those of the HFD group. Conclusion： DRG can prevent the formation of obesity and hyperlipidemia