摘要
AIM: To evaluate the potential association of xeroderma pigmentosum group D (XPD) codon 751 variant with outcome after chemo-radiotherapy in patients with resected gastric cancer. METHODS: We used PCR-RFLP to evaluate the genetic XPD Lys751Gln polymorphisms in 44 patients with stage Ⅲ (48%) and Ⅳ (20%) gastric cancer treated with surgery following radiation therapy plus 5-fluorouracil/ leucovorin based chemotherapy. RESULTS: Statistical analysis showed that 75% (12 of 16) of relapse patients showed Lys/Lys genotype more frequently (P = 0.042). The Lys polymorphism was an independent predictor of high-risk relapse-free survival from Cox analysis (HR: 3.07, 95% CI: 1.07-8.78, P = 0.036) and Kaplan-Meir test (P = 0.027, log-rank test). CONCLUSION: XPD Lys751Gln polymorphism may be an important marker in the prediction of clinical outcome to chemo-radiotherapy in resected gastric cancer patients.
AIM： To evaluate the potential association of xeroderma pigmentosum group D （XPD） codon 751 variant with outcome after chemo-radiotherapy in patients with resected gastric cancer.
METHODS. We used PCR-RFLP to evaluate the genetic XPD Lys751Gln polymorphisms in 44 patients with stage Ⅲ （48%） and Ⅳ （20%） gastric cancer treated with surgery following radiation therapy plus 5-fluorouracil/ leucovorin based chemotherapy.
RESULTS： Statistical analysis showed that 75% （12 of 16） of relapse patients showed Lys/Lys genotype more frequently （P =0.042）. The Lys polymorphism was an independent predictor of high-risk relapse-free survival from Cox analysis （HR： 3.07, 95% CI： 1.07-8.78, P = 0.036） and Kaplan-Meir test （P = 0.027, log-rank test）.
CONCLUSION： XPD Lys751Gln polymorphism may be an important marker in the prediction of clinical outcome to chemo-radiotherapy in resected gastric cancer patients.
基金
Supported by a grant from the Navarra Government 70/2004
关键词
皮肤干燥症
胃癌
化学治疗
放射治疗
Xeroderma pigmentosum group D gene
Polymorphism
Gastric cancer
Radiotherapy
