血浆血栓前体蛋白与颌面部肿瘤并发血栓的相关性研究

A Study of Thrombus Precursor Protein on Laboratory Determination of Thrombosis in Patients with Facial Tumour

目的观察血浆前体蛋白(TpP)与颌面部肿瘤患者并发血栓的相关性。方法分别对20例颌面部腺癌患者,20例颌面部非腺癌肿瘤患者和20例健康志愿者进行BPC、PT等常规检测,以及包括(TpP)在内的血小板活化、凝血纤溶激活和内皮细胞受损的分子标志物检测。并对其进行敏感度和特异性的比较。结果颌面部腺癌组的各项指标与正常对照组相比有差异(P＜0．01或P＜0．05),TpP在颌面部腺癌组的升高与其并发血栓有一定相关性。结论TpP与颌面部腺癌患者并发血栓有一定相关性,是颌面部腺癌患者并发血栓的危险性评估,采取早期抗凝治疗的特异性指标。

Objective To observe the relationship of plasma thrombs precursor proteinl （TpP） level and thrombosis in patients with facial tumour. Methods We measured indexes of routine laboratory and molecular markers in 20 cases of normal controls, 20 cases of patients with facial adenocarcinoma and 20 cases of patients with facial tumour （non-adenocarcinoma）. Results The platelet count,PT,aPTT,TT,ET-1 ,Fbg,D- D, TpP in patients with facial adenocarcinoma group had differences compared with normal controls （P 〈 0.01 or P 〈 0. 05）. The raise of TpP is related to thrombus which is complicated by facial adenocarcinoma. Conclusion TpP is related to thrombus which is complicated by facial adenocarcinoma. It might be a risk factor of thrombus in facial adenocarcinoma. TpP is also a specific index for early anti-coagulation in facial ad- enocarcinoma patients.