DNA单核苷酸钠注射液治疗急性病毒性心肌炎的临床研究

Therapeutic effect of deoxyribonucleotidum on acute viral myocarditis

目的探讨DNA单核苷酸钠注射液在急性病毒性心肌炎治疗中的作用和临床应用价值。方法将确诊为急性病毒性心肌炎的88例患者随机分成两组:对照组常规给予中西医综合治疗方法,治疗组在此基础上,加用DNA单核苷酸钠注射液,比较两组患者治疗4周后总有效率和中位症状消失时间的差异。结果治疗4周后,对照组总有效率79.54%,治疗组总有效率95.45%(P=0.049),对照组和治疗组中位症状消失时间分别为9.5和6.5d(P=0.035)。治疗组中2例患者出现血压偏低、轻微头晕,休息后缓解,无其他不良反应。结论加用DNA单核苷酸钠注射液可以提高急性病毒性心肌炎的疗效。

Objective To evaluate the therapeutic efficacy of deoxyribonucleotidum in treatment of acute viral myocarditis. Methods Eighty-eight patients with acute viral myocarditis were randomized epually into therapeutic group and control group. Patients in the control group were treated with routine treatment and those in the therapeutic group were given deoxyribonucleotidum in addition to routine treatment. After 4 weeks, the total efficacy rate and median time of symptom disappearance were compared between the two groups. Results The total efficacy rate in the control and therapeutic groups was 79.54% and 95.45% （P=-0.049）, and the median time of symptom disappearance was 9.5 days and 6.5 days, respectively （P=0.035）. Hypotension and mild dizziness were found in 2 patients in the therapeutic group without other severe side effects. Conclusion Deoxyribonucleotidum can improve the therapeutic effect for acute viral myocarditis.