胃肠功能衰竭新生儿血清二胺氧化酶和D-乳酸的测定及意义

Serum diamine oxidase and D-lactate level in neonates with gastrointestinal failure and its clinical significance

目的探讨胃肠功能衰竭新生儿血清二胺氧化酶(DAO)和D-乳酸含量变化特点及其临床意义。方法19例胃肠功能衰竭新生儿为病例组,79例健康新生儿为对照组,测量两组新生儿血清DAO、D-乳酸含量。结果对照组血清DAO含量为(8.851±3.424)U/ml,血D-乳酸含量为(0.918±0.715)μg/ml。病例组血清DAO含量为(11.610±3.909)U/ml,D-乳酸含量为(1.859±0.972)μg/ml;病例组血清DAO、D-乳酸水平显著高于对照组(P<0.05,P<0.01)。不同疾病严重程度、不同胎龄、不同日龄患儿血清DAO、D-乳酸含量比较无显著性差异(P>0.05)。结论血清DAO和D-乳酸含量测定可作为新生儿胃肠功能衰竭早期诊断的敏感指标。

Objective To investigate the levels of serum diamine oxidase （DAO） and D-lactate in neonates with gastrointestinal failure and its clinical significance. Methods Ninety-eight newborn infants were divided into two groups, nineteen neonates with gastrointestinal failure were observed as cases group and seventy-nine healthy newborn were as control, the levels of serum DAO and D-lactate in two groups were detected. Results The levels of serum DAO and D-lactate in cases group and control group were （11.610 ± 3. 909） U/ ml, （ 1. 859 ± 0.972） μg/ml and （8.851 ± 3. 424） U/ml, （0.918 ± 0.715 ） μg/ml respectively. The levels of serum DAO and D-lactate in cases group were significantly higher than those in control group. The levels of serum DAO and D-lactate in cases group were not increased in proportion with the severity of disease. There were no significant differences in the levels of serum DAO and D-lactate between premature infants and mature ones, and alto between neonates younger than 3 days and older than 3 days. Conclusion Serum DAO and D- lactate may be early markers for gastrointestinal failure in neonates.