卵巢过度刺激综合征的研究进展

The progress in ovarian hyperstimulation syndrome

卵巢过度刺激综合征(OHSS)是诱导排卵或促超排卵药物引起的严重并发症,由于过多的卵泡发育造成血管通透性增加,出现腹水、胸水、电解质紊乱、肝肾功能受损等症状,不仅影响妊娠成功率,甚至危及生命。该综合征的发病机制尚未阐明,目前只能对症处理和支持治疗,因此预防和及时发现是治疗的关键。本文就近年对OHSS的发病机制、临床分期、相关因素和预防措施等研究进展做一综述。

Ovarian hyperstimulation syndrome（OHSS） is a complication of controlled ovarian hyperstimulation and ovulatory induction. It is characterized by increase in capillary permeability of the mesothelial surface due to excessive follicles development. Its clinical syndrome includes massive ovarian enlargement, ascites, pleural effusion, oliguria, haemoconcentration and thromboembolic phenomena. The presence of OHSS not only reduces the pregnancy outcome, but also potentially threatens life. Its pathogenesis is not fully understood and no completely curative therapy for OHSS is available at present. The most effective treatment is prevention. This article will give an overview about the progress in pathogenesis, classification and the measures to prevent OHSS.