胃癌螺旋CT与病理、nm23-H_1蛋白表达的相关性研究

A Comparatively Study of Spiral CT and Pathology,the Expression of nm23-H_1 in Gastric Carcinoma

目的探讨胃癌螺旋CT征象与手术病理及nm23-H1蛋白表达间的关系。资料与方法对65例胃癌行低张力水充盈螺旋CT三期增强扫描,所有病例均行手术切除,术后标本采用免疫组织化学SP法检测肿瘤组织中nm23-H1蛋白表达。将螺旋CT诊断结果与病理结果、nm23-H1蛋白表达进行对照。结果65例胃癌TNM分期CT的准确性为80.0%(52/65),nm23-H1蛋白阳性表达率为50.8%(33/65)。CT像上的病灶大小、浆膜侵犯、淋巴结转移、TNM分期与病理结果一致性良好,与nm23-H1蛋白阳性表达率均密切相关(P<0.05)。结论螺旋CT可较准确地反映胃癌增殖、浸润转移的病理学及生物学特性。

Objective To investigate the correlation among spiral CT features and pathology, the expression of nm23-H1 in gastric carcinoma. Materials and Methods A total of 65 patients with gastric carcinoma were evaluated with triphasic spiral CT with water filling method and hypotonic agent. All the patients were performed operative excision. The protein expression of nm23-H1 was detected with immuohistochemistry. Spiral CT findings were compared with postoperative pathology and the expression of nm23-H1. Results The TNM staging accuracy of spiral CT was 80.0% （52/65） in gastric carcinoma. The positive rate of nm23-H1 protein was 50.8 % （33/65）. Spiral CT features including size, serosal invasion, lymphnode metastasis and TNM staging were correlated with postoperative pathology and the expression of nm23-H1 of gastric carcinoma （P 〈 0.05 ）. Conclusion Triphasic spiral CT can accurately reveal the size, serosal invasion, lymphnode metastasis and TNM staging of gastric carcinoma, which could help us to know the pathological and biological characteristics of proliferation, invasion and metastasis in gastric carcinoma.