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真核转录的结构生物学——2006年诺贝尔化学奖简介 被引量：1

Structural Biology of Eukaryotic Transcription:a Brief Introduction to The Nobel Prize in Chemistry 2006
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摘要 用X射线晶体学方法测定的一系列RNA聚合酶Ⅱ复合物结构揭示了真核转录的分子机制. A brief introduction to the X-ray crystallographic studies on RNA polymerase Ⅱ complexes and the enzymatic mechanisms revealed by the crystal structures.
作者 胡永林
机构地区 中国科学院生物物理研究所
出处 《生物化学与生物物理进展》 SCIE CAS CSCD 北大核心 2006年第10期918-921,共4页 Progress In Biochemistry and Biophysics
关键词 真核转录 RNA聚合酶Ⅱ 晶体结构 crystal structure, RNA polymerase Ⅱ, enzymatic mechanism
分类号 Q7 [生物学—分子生物学]
  • 相关文献

参考文献7

  • 1Cramer P,Bushnell,D A,Kornberg R D.Structural basis of transcription:RNA Polymerase Ⅱ at 2.8 Angstrom Resolution.Science,2001,292:1863 ～ 1876
  • 2Gnatt A L,Cramer P,Fu J,et al.Structural basis of transcription:an RNA polymerase Ⅱ elongation complex at 3.3 (A) resolution.Science,2001,292:1876～1882
  • 3Myers L C,Kornberg R D.Mediator of transcriptional regulation.Annu Rev Biochem,1990,69:729～749
  • 4Darst S A,Edwards A M,Kubalek E W,et al.Three-dimensional structure of yeast RNA polymerase Ⅱ at 16 (A) resolution.Cell,1991,66:121～128
  • 5Bushnell D A,Cramer P,Kornberg R D.Structural basis of transcription:α-Amanitin-RNA polymerase Ⅱ cocrystal at 2.8 (A)resolution.Proc Nat Acad Sci USA,2002,99:1218～ 1222
  • 6Westover K D,Bushnell D A,Kornberg R D.Structural basis of transcription:nucleotide selection by rotation in the RNA polymerase Ⅱ active center.Cell,2004,119:481 ～489
  • 7Westover K D,Bushnell D A,Kornberg R D.Structural basis of transcription:separation of RNA from DNA by RNA polymerase Ⅱ.Science,2004,303:1014～1016

同被引文献9

  • 1KORNBERG R D.Chromatin structure:a repeating unit of histones and DNA[J].Science,1974,184:868-871.
  • 2SAYRE M H,TSCHNOCHNER H,KORNBERG R D.Reconstitution of transcription with five purified protein factors and RNA polymerase Ⅱ from Saccharomyces cerevisiae[J].J.Biol.Chem.,1992,267:23376-23382.
  • 3KIM Y J,BJORKLUND S,LI Y,et al.A multiprotein mediator of transcriptional activation and its interaction with the Cterminal repeat domain of RNA polymerase Ⅱ[J].Cell,1994,77:599-608.
  • 4CRAMER P,BUSHNELL D A,KORNBERG R D.Structure basis of transcription:RNA polymeraseⅡ at 2.8 angstrom resolution[J].Science,2001,292:1863-1876.
  • 5GNATT A L,CRAMER P,FU J,et al.Structure basis of transcription:an RNA polymeras Ⅱ elongation complex at 3.3(A) resolution[J].Science,2001,292:1876-1882.
  • 6WESTOVER K D,BUSHNELL D A,KORNBERG R D.Structural basis of transcription:Separation of RNA from DNA by RNA polymerase Ⅱ[J].Science,2004,303:1014-1016.
  • 7WESTOVER K D,BUSHNELL D A,KORNBERG R D.Structural basis of transcription:Nucleotide selection by rotation in the RNA polymerase Ⅱ active centre[J].Cell,2004,119:481-489.
  • 8BUSHNELL D A,WESTOVER K D,DAVIS R E,et al.Structural basis of transcription:An RNA polymerase Ⅱ-TFⅡ B Cocrystal at 4.5 angstroms[J].Science,2004,303:983-988.
  • 9The Royal Swedish Academy of Sciences.Advanced information on the Nobel Prize in 2006:Molecular basis of eukaryotic transcription[EB/OL].Www.kva.se.

引证文献1

生物化学与生物物理进展
2006年 第10期

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