婴幼儿血管瘤病理结构变化与临床演变过程的联系

The relation between the pathologic structure and the clinical evolution of infantile hemangioma

目的探讨婴幼儿血管瘤患者临床演变过程和病理结构变化的内在联系。方法选取52例婴幼儿血管瘤标本，年龄2个月至11岁。采用HE染色观察各阶段血管瘤的病理特点，使用图像分析系统分析血管瘤组织中的细胞总数量、微血管总数量和总面积。结果按患儿出生后时间：1～6个月，血管瘤中细胞增殖速度快、排列紧密，微血管数量迅速增加；7～12个月，血管瘤中细胞数量迅速减少，微血管数量减少，但总面积继续扩大；1～3岁，大部分血管瘤组织呈微血管团样，微血管面积最大；3～5岁，微血管数量和总面积均迅速减少；5岁之后，大部分血管瘤消退完成．被纤维脂肪组织代替。结论婴幼儿血管瘤患者临床演变过程和病理结构变化有密切联系，病理结构变化主导临床演变过程。

Objective To research the relation between the pathologic structure and the clinical evolution of infantile hemangioma （IH）. Methods Fifty - two samples from infantile hemangioma were included in our study. The pathologic structure were observed and the number of cells, the number and area of the microvessels in the tumor were analyzed by the imaging analysis system. Results During the first 1 -- 6 months after birth, the infantile hemangioma cells proliferated very rapidly and they aggregated very tightly. The number of microvessels also increased quickly. Between the 7th to 12th month, the number of cells and microve.ssels decreased. But the area of microvessels increased. Between the lnd to 3rd year, most of infantile hemangiomas were composed of plenty of microvessels and the area of microvessels was the largest. Between 3th to 5th year, the number and area of microvessels decrease quickly, After 5 years old, most of hemangiomas involuted completely and were replaced by the fat and fiber tissue. Conclusion There existed close relation between the pathologic structure and the clinical evolution of infantile hemangioma. The changs of pathologic structure led to the clinical evolution.