高压氧治疗新生儿缺氧缺血性脑病的临床疗效

Clinical effection of hypoxic and ischemic encephalopathy treated by hyperbaric oxygen.

【目的】研究高压氧干预治疗新生儿缺氧缺血性脑病对新生儿神经行为评分的影响及头颅CT变化的影响。【方法】观察组在常规治疗基础上于病程5 d内加用高压氧,两组患儿均于治疗前后由专人盲法进行神经行为评分测定,三个疗程后复查头颅CT。【结果】高压氧治疗组神经行为评分明显高于对照组,三个疗程后复查头颅CT高压氧组低密度灶吸收明显优于对照组,且无毒副作用。【结论】高压氧治疗新生儿缺氧缺血性脑病近期的临床疗效可靠、安全。

[Objectives] To explore the effection of neonatal neurological behaviroral scores and Computed Tomo- graphy（CT） of brain of hypoxic and ischemic encephalopathy（HIE） treated by hyperbaric oxygen. [Methods] Seventyfive patients with HIE were divided into two groups randomly, one was treated by hyperbaric oxygen（HBO） on the basis of routine therapy, the other treated by routine therapy was control group, Neonatal Behavioral Neurological Assessment （NBNA） of two groups were determined blindly before and after treatment,CT of brain were counterchecked after three periods of treatment. [Result] The scores of NBNA of HBO group were higher significantly than those of control group, compared to control group, low-density range of CT of brain were absorbed obviously in HBO group, and no obvious side-effect was found. [Conclusion] Hyperbaric oxygen is a safety and effective treatment to neonatal HIE.