经导管超选择动脉灌注化疗在中晚期鼻咽癌综合治疗中的价值

The clinical value of combination of transcatheter superselective intra-arterial chemotherapy in the combined treatment of advanced nasopharyngeal carcinoma

目的探讨中晚期鼻咽癌(Ⅲ,Ⅳa期)放疗前选择性动脉插管化疗(IACT)应用价值。方法选择60例局部晚期鼻咽癌初治患者,随机分成2组各30例,放疗前分别进行IACT和静脉化疗(IVCT),于放疗后4周对2组的疗效进行比较。结果IACT组、IVCT组有效率及1年局控率分别为93.33%,70.00%和92.86%,71.43%,两组比较差异有统计学意义(P<0.05)。结论选择性动脉插管化疗联合放疗治疗中晚期鼻咽癌,短期疗效显著,局控率高,毒副作用轻。

Objective To evaluate the clinical value of selective arterial chemotherapy after radiotherapy for advanced nasopharyngeal carcinoma （stageⅢ,Ⅳa）. Methods Sixty patients with advanced nasopharyngeal carcinoma were randomized to receive either combined elective arterial chemotherapy and radiotherapy （IACT group, 30 patients） or combined general intravenous chemotherapy and radiotherapy（IVCT- group, 30 patients）. Four weeks after radiotherapy, tbe effect of two methods was compared. Results The efficiency rate and the 1-year local disease control rate were 93.33 %, 92.86 % in IACT and 70.00 %, 71.43 % in IVCT, respectively. There were outstanding differences between the two groups（P 〈 0.05）. Conclusion The short-term therapeutic results of selective arterial chemotherapy combined with radiotherapy in advanced nasopharyngeal carcinoma was obviously effective, the local control rate were high, the side effect were slight.