2型糖尿病患者血清瘦素水平及临床意义

Clinical Significance of Determination of Serum Lept in Levels in Patients with Type 2 Diabetes Mellitus

目的:观察2型糖尿病(DM2)患者血清瘦素(leptin)水平及其与肥胖、血糖、血脂的关系。方法:采用放射免疫分析(R IA)测定42例DM2患者和38例正常对照组的血清leptin水平。结果:DM2组血清leptin水平明显高于对照组(P<0.01);血清leptin与体重指数(BM I)、血清胰岛素(INS)、总胆固醇(TC)、甘油三酯(TG)、脂蛋白LDL-C呈正相关。结论:DM2患者的高leptin血症与肥胖、血脂异常及胰岛素抵抗(IR)密切相关。

Objective To investigate the relationship between levels of serum leptin and levels of blood sugar, lipid as well as degree of obesity in patients with type 2 diabetes mellitus （DM2）. Methods Serum leptin levels were determined with RIA in 42 patients with DM2 and 38 controls. Results The serum leptin levels in DM2 patients were significantly higher than those in controls （P 〈 0.001） and were positively correlated with serum INS, TC, TG, LDL - C levels as well as BMI. Conclusion High level of serum leptin was associated with obesity, high blood lipid levels and insulin resistance （IR）.